ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of embolization of bronchial artery (BAE) in patients with pneumoconiosis massive hemoptysis.</p><p><b>METHODS</b>49 patients with pneumoconiosis massive hemoptysis in observation group were underwent BAE, and 66 patients with pneumoconiosis hemoptysis in control group were cured with internal medicine. The rate of hemoptysis recurrence and controlling were counted during a year follow up.</p><p><b>RESULTS</b>The rate of hemoptysis recurrence in observation group was 18.8% (9/48), and in control group was 35.9% (23/64) during a year follow up, there was a significant difference (P < 0.05). The rate of massive hemoptysis recurrence in the both group were 4.2% (2/48) and 9.3% (6/64) respectively, there was not a significant difference (P > 0.05).</p><p><b>CONCLUSION</b>BAE is an effective technique in patients with pneumoconiosis massive hemoptysis.</p>
Subject(s)
Humans , Bronchial Arteries , Embolization, Therapeutic , Hemoptysis , Therapeutics , Pneumoconiosis , Therapeutics , Recurrence , Treatment OutcomeABSTRACT
<p><b>OBJECTIVE</b>To establish a rabbit model of silicotic pulmonary fibrosis and to investigate the effect of cordyceps sinensis in this model.</p><p><b>METHODS</b>Thirty healthy male white rabbits were randomly divided into control group, silicosis model group, and intervention group. The rabbits in silicosis model group and intervention group received endotracheal perfusion of silicon dioxide suspension (120 mg/kg), and the control group was treated with the same volume of saline. All the rabbits were sacrificed 30 days later. The lung coefficient was calculated by comparing the lung weight and body weight; the right lung tissue was stained with hematoxylin-eosin (HE). The content of hydroxyproline in lung tissue was measured by alkaline hydrolysis. The mRNA levels of transforming growth factor beta 1 (TGF-β₁) and mothers against decapentaplegic homolog 7 (Smad7) in rabbit lung sections were determined by real-time PCR.</p><p><b>RESULTS</b>No abnormalities were observed by HE staining in the lung tissues of control group, while fibrosis and silicotic nodules were discovered in the silicosis model group and intervention group. The lung coefficient and the content of hydroxyproline in lung tissue were significantly higher in the silicosis model group than in the control group and intervention group (P < 0.05 or P < 0.01). Compared with the control group, the silicosis model group and intervention group had significantly increased TGF-β₁ mRNA levels but significantly reduced Smad7 mRNA levels (P < 0.02). Compared with the silicosis model group, the intervention group had a significantly reduced TGF-β₁ mRNA level but a significantly increased Smad7 mRNA level (P < 0.05).</p><p><b>CONCLUSION</b>Cordyceps sinensis is able to reduce the expression of TGF-β₁ mRNA and increase the expression of Smad7 mRNA in lung tissues of rabbits with silicotic pulmonary fibrosis, and thus postpone the progression of fibrosis.</p>
Subject(s)
Animals , Male , Rabbits , Cordyceps , Chemistry , Disease Models, Animal , Lung , Metabolism , Pulmonary Fibrosis , Drug Therapy , Metabolism , Silicosis , Drug Therapy , Metabolism , Smad7 Protein , Metabolism , Transforming Growth Factor beta1 , MetabolismABSTRACT
AIM: To explore the immunologic effect of extra bacillus calmette guerin (EBCG) on asthmatic patients. METHODS: 58 asthmatic patients in acute exacerbation were randomly enrolled into two groups: EBCG group (n=34) and control group (n=24). Before treatment, the levels of interleukin 4 (IL 4) and interleukin 12 (IL 12) in blood plasma were examined in both groups. The patients in EBCG group inhaled budesonide aerosol according to asthmatic ladder treatment program and injected with EBCG. Spasmolytic could be used if necessary (excluding theophylline) .The patients in control group only used budesonide aerosol and spasmolytic. The level of IL 4 and IL 12 in blood plasma were determined again after three months. RESULTS: After the drug intervention, the level of IL 4 significantly decreased in EBCG group ( 29.0 ? 5.6 vs 22.6 ? 6.5 ng?L -1 ,P 0.05 ). Before drug intervention, no significant differences were found between two groups in IL 4 and IL 12 concentrations; However, there were markedly differences after drug intervention (P